In Korea. B-type hepatitis is a disease with high morbidity. Entering the 1980´s, the B-type hepatitis vaccine was produced domestically and studies on its immunity effects were subsequently activated. The studies focus on measureing the surface-antibody-positive-rate(SAPR) for each parameter influencing the vaccine´s immunity effects. However, it is difficult to generalize the resulting values, which range widely or show inconsistency.
This study was implemented to obtain generalized and comprehensive results by analyzing narratively and quantitatively, through a meta-analysis data from the indivisual studies which yielded the following conclusions :
1. In the case of SAPR by sex, the rate for females were higher than for males.
2. In the case of SAPR by age, it is impossible to get overall combined estimate because applied criteria were different. But no significant differences by age were found in all of 7 tested theses.
3. As for the vaccinated dose. school children with vaccinations of half the recommended dose showed the higher SAPR, but this was shown to be statistically insignificant. It appeared that the quantitatively-reduced vaccination for nenates did not lower their ability to produce antibodies.
4. In the case of SAPR by kinds of vaccines. heat-treated hepaccine showed the highest rate out of human plasma. while the DNA recombinant vaccine showed. on the whole, higher rate than Hepavax-B.
5. In the case of SAPR by injection frequency, the rate for the muscular injection group was significantly high subject to the first and second injection, but any differences after the third injection were not found.
6. In the case of SAPR by injection intervals, the rate for the 0-1-2 group was significantly high in comparison with the rate for the 0-1-6 group subject to first injection but thereafter no differences were found.
7. The SAPR in anti-HBc positive was found to be higher than in negatives.
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